Maternal Rh-immunization.

Incidence of maternal Rh immunization by ABO compatible and incompatible pregnancies.

The incidence of maternal Rh immunization in Rh-negative women following a single ABO compatible Rh-positive pregnancy is about 17%. This incidence was determined by following Rh-negative women through two Rh-incompatible pregnancies and analysing their sera for anti-Rh at the time of delivery of their second observed pregnancy. Maternal Rh immunization occurs almost exclusively after delivery;...

Further factors influencing Rh-immunization: II.

Primary immunization of Rh-negative volunteers.

To determine the best method for the production of high-titre anti-D serum primary immunization was carried out in two groups of Rh-negative male volunteers with washed group O R(2)R(2) cells. The first group of six men were given 5 ml. of packed cells, and the second group of five men were given 0.5 ml. of packed cells, in each instance by intravenous injection. Only one individual in each gro...

Abo Blood Groups and Rh Iso-immunization.

Levine (1943, 1958a, b, 1959) observed that Rh isoimmunization of Rh-negative women was relatively much morecommon inwomen with ABO-compatible husbands than in women with ABO-incompatible husbands. This observation has implications with regard to the incidence of the ABO blood groups in affected families, and certain of these implications were first noted by Lucia and Hunt (1950a, b) in respect...

Spina bifida and maternal Rh blood type.